منابع مشابه
Genetic polymorphism and drug-induced movement disorders.
Sir: We were interested to read the paper by Armstrong et a1 (1997) on drug-induced movement disorders in relation to the CYP2D6 genotype. We would agree that this important polymorphism may well be a contributory factor in more chronic druginduced movement disorders. G. D. I. Bates Blrm~ngham Children's Hospital. Ladywood M~ddleway, Ladywood, Birmtngham B16 8ET A. E. van Woerkom, 0. Lopes Quee...
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PURPOSE Dose-limiting toxicities of docetaxel are widely considered to be neutropenia, anemia, skin toxicity, and nausea. One of the factors that limit the use of docetaxel is its unpredictability of inter-individual variation in toxicity. MATERIALS AND METHODS In order to identify the genetic factors that affect the risk of docetaxel-induced toxicities, we recruited patients who received doc...
متن کاملGenetic Polymorphism of CYP2C19 in Pakistani Population
CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...
متن کاملGenetic Polymorphism of CYP2C19 in Pakistani Population
CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...
متن کاملDrug transporters in spermatogenesis
Drug transporters are integral membrane proteins expressed by a variety of organs, including the liver, kidney, small intestine and testis, and they are generally known to mediate drug or xenobiotic transport into and out of cells. Previous studies have also reported the presence of several drug transporters at blood-tissue barriers where they are thought to protect organs from harmful agents. ...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 2000
ISSN: 0916-1139
DOI: 10.2133/dmpk.15.supplement_94